The 11th Chinese International Peptide Symposium CPS-2010,
hosted by Lanzhou University, was held in Lanzhou, China, July 5-8,
2010. More than 300 participants, from 12 countries and districts
as well as represents from 30 or so related companies attended this
symposium. Thus, it was gratifying to see that this meeting
retained both its international flavor and participants loyalty at
a time when there are a great many symposia held each year on
similar subjects. The goal of this symposium was to provide a forum
for exchange of ideas, review of the progress in the field of
peptide research, encourage the cooperation between the
international and Chinese scientific communities. We believe that
this goal had been achieved.
The scientific program, thanks to the insights and efforts of the
program committee, was extraordinary rich, diverse and exciting. It
was comprised of 14 sessions with 22 plenary lectures, 37 invited
lectures and 116 poster presentations, concerning bioactive
peptides, peptide immunology, structure and conformation of
peptides and proteins, molecular diversity and peptide libraries,
synthetic methods, de novo design and synthesis of proteins and
peptides, ligand-receptor interactions, the
chemistry-biology-interface, self-assembling peptides and
challenging problems in peptides.
Dr. John D. Wade and Dr. Yanmei Li were the recipients of ‘Cathay
Award’ sponsored by H. H. Liu Education Foundation, offering their
seminal contributions to peptide science and the Chinese
International Peptide Symposium. Dr. Saburo Aimoto and Dr. Luhua
Lai were the recipients of ‘Xiaoyu Hu Memorial Award’ sponsored by
Hainan Zhonghe Group Co. Ltd, offering their great contributions
in peptide science, peptide application and Chinese International
Peptide Symposium. Especially, it should be mentioned that ‘Xiaoyu
Hu Memorial Award’ was first set up at the 11th CPS to commemorate
Professor Xiaoyu Hu for his great contribution to the development
of peptide science and peptide application in China. Four young
outstanding scientists were selected by the International Program
Committee to receive the Young Peptide Scientist Award , which was
sponsored by Hainan Zhonghe Group Co. Ltd.
The enthusiastic cooperation and prominent contributions were
gratifying and the active response of the invited speakers
contributed to the success of the symposium. The presentations were
of excellent caliber and represented the most current and
significant aspects of peptide science.
I would like to acknowledge academicians of chinese academy of
sciences, Professor Youshang Zhang and Professor Yundong Wu for
their kindness in supporting and serving as the chairman of the
awarding committee for the ‘Cathay Award’ and ‘Xiaoyu Hu Memorial
Award’ respectively. The success of the 11th CPS was largely due to
the dedication, enthusiasm and hard work of the local organizing
committee, who for the most part consisted of volunteers. As
Symposium Chair, I am appreciated for their contributions very
much.
目錄：
Preface Ⅴ
The Eleventh Chinese Peptide Symposium CPS-2010 Ⅶ
Acknowledgments Ⅹ
Cathay Award Ⅺ
Xiaoyu Hu Memorial Award Ⅻ
Chinese Peptide Symposium ⅩⅢ
Abbreviations ⅩⅣPreface
The Eleventh Chinese Peptide Symposium CPS-2010
Acknowledgments
Cathay Award
Xiaoyu Hu Memorial Award
Chinese Peptide Symposium
Abbreviations
Session 1 Design of Peptides and Mimetics 1
Biomimetic Nanostructures Based on Enforced Folding and Assembly
3
Bing Gong
Agonist vs. Antagonist Behavior of Opioid Peptides Containing
Novel
Tyrosine or Phenylalanine Analogues in Place of Tyr1 13
Grazyna Weltrowska, Irena Berezowska, Brian C. Wilkes, Carole
Lemieux,
Nga N. Chung, Jinguo Ding, Yixin Lu, Peter W. Schiller,
Novel Non-Peptide Ghrelin Receptor Ligands Based on
3,4,5-Trisubstituted 1,2,4-Triazoles 20
Jean-Alain Fehrentz, Anne-Laure Blayo, Mathieu Bibian, Aline
Moulin, Luc
Demange, Damien Boeglin, Céline M’Kadmi, Jean-Claude
Galleyrand,
Didier Gagne, Vittorio Locatelli, Antonello Torsello, Daniel
Perrissoud,
Jean Martinez,
Synthesis and Structure-Activity Relationship of
Marinostatin,
An Ester-Linked Serine Protease Inhibitor 25
Misako Taichi, Toshimasa Yamazaki, Tadashi Teshima, Yuji
Nishiuchi
Mitocryptides: A Novel Family of Neutrophil-Activating Peptides
Derived
from Mitochondrial Proteins and Their Regulatory Mechanisms
30
Hidehito Mukai, Tetsuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso
Novel Opioid Peptide Derived Antagonists Containing 3-2,6-
Dimethyl-4-
Carbamoylphenyl-Propanoic Acid Dcp in Place of Tyr1 33
Peter W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, Carole
Lemieux,
Nga N. Chung, Tze Keong Lum, Yoon Wui Leow Augustine, Yixin
Lu
Design, Synthesis and Evaluation of Antitumor Activity
against
Human Cancer Cell Lines, Sansalvamide Analogues 39
Xiaoli Zhen, Yihua Yang, Junzhang Li, Xia Tian, Hua Zhang, Shouxin
Liu
Session 2 Peptide Synthesis and Preparation 41
Regioselective Disulfide Bond Formation during SPS of Human
Relaxin-3:
Evaluation of An Alternative Method for Removal of the S-Acm Groups
via
Reaction with Silver Triflate and Subsequent Mild Aqueous
DMSO Oxidation 43
Feng Lin, John D. Wade
Synthetic Studies of Membrane Proteins: Subunit C of Human
F1Fo-ATP
Synthase and Voltage Sensor Only Protein 78-222 47
Saburo Aimoto, Ken’ichiro Nakamura, Takeshi Sato, Toru
Kawakami,
Toshiaki Hara
One-Pot Synthesis of Rigid Cyclic N-Methyl-γ-Peptides 54
Zhongzhu Chen, Liangchun Li, Menglan Lv, Jin Zhu and Jingen
Deng
Tbfmoc Methioine: Its Synthesis and Application for the Solid
Phase
Synthesis of Ubiquitin Analogues and Product Purification 58
Naifeng Hu, Zhi Jin, Pu Wang
Intein-Mediated Biosynthesis of Bracelet Cyclotide 63
Xinya Hemu, Lin Cai, Clarence T. T. Wong, James P. Tam
Convergent and Atom-Economic Synthesis of Phosphinopeptides
67
Fanhua Meng, Jiaxi Xu
One-Step Oxidative Folding of A Novel Cystine-Knot Cyclotide
Under Denaturation Conditions 69
Clarence T. T. Wong, Misako Taichi, Hideki Nishio, Yuji
Nishiuchi,
James P. Tam
Synthesis of Angiotensin I-Converting Enzyme Inhibitory Peptides
and
Their Self-Assembling Microstructure Characterization 72
Dawei Li, Yan Ding, Gang Cao, Ruijie Zhang, Jin Ren, Chuanguang
Qin
Fast Automated Synthesis of An Antimicrobial Peptide Analog
Using UV-Monitoring on the Tribute? 77
German E. Fuentes, Christina A. Chantell, Hirendra Patel,
Mahendra
Menakuru
Synthesis of Cyclic Peptides by Alknye-Azide Click Chemistry
Cyclization 81
Liangyou Wang, Dongdong Lu, Mingxing Lu
Thioester Preparation through O-S Acyl Shift under Acidic Condition
83
Khee Dong Eom, Young Soon Shin, James P. Tam
A Novel Strategy for Total Solid-Phase Synthesis of
Kahalalide A Derivatives 86
Tingting Wei, Jin Ren, Xiaoya Shang, Gang Cao, Chuanguang Qin
Session 3 Methodologies in Peptide Research 91
Protein Synthesis Using Novel Ligation Partners 93
Wen Hou, Renliang Yang, Fupeng Li, Xiaohong Zhang, Chuanfa
Liu
Expanding Role of Mass Spectrometry for Characterization of
Proteins 97
Pui-kin So, Zhongping Yao
Effect of pH on the Self-Assembly of Surfactant-Like Peptides
102
Shuyi Han, Jing Wang, Hai Xu
Conformational Isomers in N-Methylzygosporamide Cyclic
Pentapeptides 110
Yihua Yang, Shirui Gao, Xianrui Yuan, Shouxin Liu, Wei Meng, Guodi
Qi
Interaction between Amyloid-β-Peptide 1-40 and Its
Aggregation
Inhibitors Studied by Circular Dichroism 112
Qing Zeng
Disulfide Bond Formation Directed by Watson-Crick Base Pairing
116
Fupeng Li, Xiaohong Zhang, Wen Hou, Chuanfa Liu
Interfacial Adsorption of Novel Lipopeptide Surfactant C14K3: A
Combined
Study of Spectroscopic Ellipsometry and Neutron Reflection
120
Donghui Jia, Kai Tao, Jiqian Wang, Xiubo Zhao, Hai Xu, John R.
P.
Webster, Jian R. Lu
Session 4 Peptide Therapeutics and Application 135
Peptide-Based Nanoparticles for Cancer Therapy and Imaging
137
Yuanpei Li, Kai Xiao, Juntao Luo, Wenwu Xiao, Joyce Lee,
Lorenzo Berti, Kit S. Lam
Involvement of Na+,K+-ATPase in Leukemia Cell Apoptosis
by Modulating Sensitivity 145
Wu Yin, Wei Cheng, Wei Chen, Dan Cao, Su Feng, Xinyin Chen, Jin
Zhao,
Yilin Shi, Zichun Hua
Short Constrained Dipeptide Mimic Oligomers as Uncharged Cell
Penetrating Compounds 157
Lubomir L. Vezenkov, Christophe André, David Paramelle, Marie
Maynadier,
Jean-Francois Hernandez, Marcel Garcia, Monique Calmès, Gilles
Subra,
Ettore Benedetti, Jean Martinez, Muriel Amblard
Synthesis and Biological Properties of Peptide-siRNA Conjugates
161
Zhenjun Yang, Xiaofeng Wang, Yang Liu, Yue Chen, Feilin Nie, Lihe
Zhang
FGF-P Facilitates Cell Proliferation Following Ionizing Radiation
167
Yeping Tian, Shanmin Yang, Mei Zhang, Yongbing Cao, Bingrong
Zhang,
Lei Zhang, Liangjie Yin, Kunzhong Zhang, Steven G. Stwarts, Bruce
M.
Fentona, Paul Okunieff, Lurong Zhang
Synthesis, Evaluation and Molecular Modeling Study of
L-2-amino-78-
Bromoalkanoic Acid Derivatives as Histone Deacetylase Inhibitors
172
Dawei Huang, Xiaohui Li , Zhilong Xiu, Norikazu Nishino
Thirteen-Membered Cyclic Tetrapeptides as Histone Deacetylase
Inhibitors 177
Hongfang Chi, Yasuhiko Otsuka, Tamaki Kato, Norikazu Nishino,
Akihiro Ito, Minoru Yoshida
Antimicrobial Peptide May be Desirable Candidate for the Treatment
of
Multidrug-Resistant Cancer Bacteria: A Simple Introduction to
the
Therapeutic Effects of A Novel Antimicrobial Peptide Polybia-MPI
182
Kairong Wang, Bangzhi Zhang, Jiexi Yan, Wei Zhang, Ru Chen,
Jingjing Song, Rui Wang
Remodeling of Cyclic Tetrapeptides Framework of Chlamydocin
as
Histone Deacetylase Inhibitors 188
Jiani Li, Xiaohui Li, Yasuhiko Otsuka, Tamaki Kato, Norikazu
Nishino,
Akihiro Ito, Minoru Yoshida
Identification of Novel HLA-A*0201-Restricted Cytotoxic T
lymphocyte Epitopes from PLAC1 in Breast Cancer 192
Wei Liu, Mingxia Zhai, Chao Dai, Yuanming Qi, Yanfeng Gao
Session 5 Bioactive Peptides and Pharmacology 197
In Vitro Characterization for the Effects of Insect Kinins on
Mouse
Distal Colonic Motility 199
Longfei Yang, Yang Xiao, Yun Huang, Guoning Ma, Zhiyuan Cong,
Shouliang Dong
Evaluation of the Bioequivalence of the 20 mg 10 ml Doses of
Two
Injectable Preparations of Eptifibatide: A Randomized,
Open-Label,
Two-Period Crossover Study in Healthy Adult Male Chinese Volunteers
204
Yanhui Gao, Baoqiu Li, Jun Sun
The Characteristics of Sleep-Wake States and Potential
Neuronal
Targets for Neuropeptide S 210
Peng Zhao, Yufeng Shao, Min Zhang, Kun Fan, Rui Wang, Yiping
Hou
Antibacterial Activity of Surfactant-Like Linear Amphipathic
Cationic Peptides 218
Jing Hu, Cui X. Chen, Sheng Z. Zhang, Hai Xu, Jian R. Lu
Comparison of the Pharmacological Functions of the NPFF1
and NPFF2 Receptors Ligands 229
Quan Fang, Ning Li, Rui Wang
Preparation of Monomeric B27 Lys Destripeptide Insulin by
Intein Mediated Expression in E. Coli 236
Lujuan Li, Helong Hao, Yuanhao Qiao, Ting Chen
Endomorphins Prevent Cardiac Oxidative Damage Induced
by Cadmium Chloride in Rats 241
Pin Gong, Fuxin Chen, Rui Wang
Study on Anticancer Mechanism of Cyclic Tetrapeptide HDACIs
246
Shimiao Wang, Xiaohui Li, Zhilong Xiu, Norikazu Nishino 246
Biological Roles of Hemokinin-1: A Novel Member of
the Tachykinin Family 251
Ziqing Kong, Wenle Yang, Caiyun Fu, Youli Zhao, Yan Tao, Rui
Wang
Author Index 257
Subject Index 260
Session 1 Design of Peptides and Mimetics
Biomimetic Nanostructures Based on Enforced Folding and
Assembly
Bing Gong
Agonist vs. Antagonist Behavior of Opioid Peptides Containing
Novel
Tyrosine or Phenylalanine Analogues in Place of Tyr1
Grazyna Weltrowska, Irena Berezowska, Brian C. Wilkes, Carole
Lemieux,
Nga N. Chung, Jinguo Ding, Yixin Lu, Peter W. Schiller,
Novel Non-Peptide Ghrelin Receptor Ligands Based on
3,4,5-Trisubstituted 1,2,4-Triazoles
Jean-Alain Fehrentz, Anne-Laure Blayo, Mathieu Bibian, Aline
Moulin, Luc
Demange, Damien Boeglin, Céline M’Kadmi, Jean-Claude
Galleyrand,
Didier Gagne, Vittorio Locatelli, Antonello Torsello, Daniel
Perrissoud,
Jean Martinez,
Synthesis and Structure-Activity Relationship of
Marinostatin,
An Ester-Linked Serine Protease Inhibitor
Misako Taichi, Toshimasa Yamazaki, Tadashi Teshima, Yuji
Nishiuchi
Mitocryptides: A Novel Family of Neutrophil-Activating Peptides
Derived
from Mitochondrial Proteins and Their Regulatory Mechanisms
Hidehito Mukai, Tetsuo Seki, Akiyoshi Fukamizu, Yoshiaki Kiso
Novel Opioid Peptide Derived Antagonists Containing 3-2,6-
Dimethyl-4-
Carbamoylphenyl-Propanoic Acid Dcp in Place of Tyr1
Peter W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, Carole
Lemieux,
Nga N. Chung, Tze Keong Lum, Yoon Wui Leow Augustine, Yixin
Lu
Design, Synthesis and Evaluation of Antitumor Activity
against
Human Cancer Cell Lines, Sansalvamide Analogues
Xiaoli Zhen, Yihua Yang, Junzhang Li, Xia Tian, Hua Zhang, Shouxin
Liu
Session 2 Peptide Synthesis and Preparation
Regioselective Disulfide Bond Formation during SPS of Human
Relaxin-3:
Evaluation of An Alternative Method for Removal of the S-Acm Groups
via
Reaction with Silver Triflate and Subsequent Mild Aqueous
DMSO Oxidation
Feng Lin, John D. Wade
Synthetic Studies of Membrane Proteins: Subunit C of Human
F1Fo-ATP
Synthase and Voltage Sensor Only Protein 78-222
Saburo Aimoto, Ken’ichiro Nakamura, Takeshi Sato, Toru
Kawakami,
Toshiaki Hara
One-Pot Synthesis of Rigid Cyclic N-Methyl-γ-Peptides
Zhongzhu Chen, Liangchun Li, Menglan Lv, Jin Zhu and Jingen
Deng
Tbfmoc Methioine: Its Synthesis and Application for the Solid
Phase
Synthesis of Ubiquitin Analogues and Product Purification
Naifeng Hu, Zhi Jin, Pu Wang
Intein-Mediated Biosynthesis of Bracelet Cyclotide
Xinya Hemu, Lin Cai, Clarence T. T. Wong, James P. Tam
Convergent and Atom-Economic Synthesis of Phosphinopeptides
Fanhua Meng, Jiaxi Xu
One-Step Oxidative Folding of A Novel Cystine-Knot Cyclotide
Under Denaturation Conditions
Clarence T. T. Wong, Misako Taichi, Hideki Nishio, Yuji
Nishiuchi,
James P. Tam
Synthesis of Angiotensin I-Converting Enzyme Inhibitory Peptides
and
Their Self-Assembling Microstructure Characterization
Dawei Li, Yan Ding, Gang Cao, Ruijie Zhang, Jin Ren, Chuanguang
Qin
Fast Automated Synthesis of An Antimicrobial Peptide Analog
Using UV-Monitoring on the Tribute?
German E. Fuentes, Christina A. Chantell, Hirendra Patel,
Mahendra
Menakuru
Synthesis of Cyclic Peptides by Alknye-Azide Click Chemistry
Cyclization
Liangyou Wang, Dongdong Lu, Mingxing Lu
Thioester Preparation through O-S Acyl Shift under Acidic
Condition
Khee Dong Eom, Young Soon Shin, James P. Tam
A Novel Strategy for Total Solid-Phase Synthesis of
Kahalalide A Derivatives
Tingting Wei, Jin Ren, Xiaoya Shang, Gang Cao, Chuanguang Qin
Session 3 Methodologies in Peptide Research
Protein Synthesis Using Novel Ligation Partners
Wen Hou, Renliang Yang, Fupeng Li, Xiaohong Zhang, Chuanfa
Liu
Expanding Role of Mass Spectrometry for Characterization of
Proteins
Pui-kin So, Zhongping Yao
Effect of pH on the Self-Assembly of Surfactant-Like Peptides
Shuyi Han, Jing Wang, Hai Xu
Conformational Isomers in N-Methylzygosporamide Cyclic
Pentapeptides
Yihua Yang, Shirui Gao, Xianrui Yuan, Shouxin Liu, Wei Meng, Guodi
Qi
Interaction between Amyloid-β-Peptide 1-40 and Its
Aggregation
Inhibitors Studied by Circular Dichroism
Qing Zeng
Disulfide Bond Formation Directed by Watson-Crick Base
Pairing
Fupeng Li, Xiaohong Zhang, Wen Hou, Chuanfa Liu
Interfacial Adsorption of Novel Lipopeptide Surfactant C14K3: A
Combined
Study of Spectroscopic Ellipsometry and Neutron Reflection
Donghui Jia, Kai Tao, Jiqian Wang, Xiubo Zhao, Hai Xu, John R.
P.
Webster, Jian R. Lu
Session 4 Peptide Therapeutics and Application
Peptide-Based Nanoparticles for Cancer Therapy and Imaging
Yuanpei Li, Kai Xiao, Juntao Luo, Wenwu Xiao, Joyce Lee,
Lorenzo Berti, Kit S. Lam
Involvement of Na+,K+-ATPase in Leukemia Cell Apoptosis
by Modulating Sensitivity
Wu Yin, Wei Cheng, Wei Chen, Dan Cao, Su Feng, Xinyin Chen, Jin
Zhao,
Yilin Shi, Zichun Hua
Short Constrained Dipeptide Mimic Oligomers as Uncharged Cell
Penetrating Compounds
Lubomir L. Vezenkov, Christophe André, David Paramelle, Marie
Maynadier,
Jean-Francois Hernandez, Marcel Garcia, Monique Calmès, Gilles
Subra,
Ettore Benedetti, Jean Martinez, Muriel Amblard
Synthesis and Biological Properties of Peptide-siRNA
Conjugates
Zhenjun Yang, Xiaofeng Wang, Yang Liu, Yue Chen, Feilin Nie, Lihe
Zhang
FGF-P Facilitates Cell Proliferation Following Ionizing
Radiation
Yeping Tian, Shanmin Yang, Mei Zhang, Yongbing Cao, Bingrong
Zhang,
Lei Zhang, Liangjie Yin, Kunzhong Zhang, Steven G. Stwarts, Bruce
M.
Fentona, Paul Okunieff, Lurong Zhang
Synthesis, Evaluation and Molecular Modeling Study of
L-2-amino-78-
Bromoalkanoic Acid Derivatives as Histone Deacetylase
Inhibitors
Dawei Huang, Xiaohui Li , Zhilong Xiu, Norikazu Nishino
Thirteen-Membered Cyclic Tetrapeptides as Histone Deacetylase
Inhibitors
Hongfang Chi, Yasuhiko Otsuka, Tamaki Kato, Norikazu Nishino,
Akihiro Ito, Minoru Yoshida
Antimicrobial Peptide May be Desirable Candidate for the Treatment
of
Multidrug-Resistant Cancer Bacteria: A Simple Introduction to
the
Therapeutic Effects of A Novel Antimicrobial Peptide
Polybia-MPI
Kairong Wang, Bangzhi Zhang, Jiexi Yan, Wei Zhang, Ru Chen,
Jingjing Song, Rui Wang
Remodeling of Cyclic Tetrapeptides Framework of Chlamydocin
as
Histone Deacetylase Inhibitors
Jiani Li, Xiaohui Li, Yasuhiko Otsuka, Tamaki Kato, Norikazu
Nishino,
Akihiro Ito, Minoru Yoshida
Identification of Novel HLA-A*0201-Restricted Cytotoxic T
lymphocyte Epitopes from PLAC1 in Breast Cancer
Wei Liu, Mingxia Zhai, Chao Dai, Yuanming Qi, Yanfeng Gao
Session 5 Bioactive Peptides and Pharmacology
In Vitro Characterization for the Effects of Insect Kinins on
Mouse
Distal Colonic Motility
Longfei Yang, Yang Xiao, Yun Huang, Guoning Ma, Zhiyuan Cong,
Shouliang Dong
Evaluation of the Bioequivalence of the 20 mg 10 ml Doses of
Two
Injectable Preparations of Eptifibatide: A Randomized,
Open-Label,
Two-Period Crossover Study in Healthy Adult Male Chinese
Volunteers
Yanhui Gao, Baoqiu Li, Jun Sun
The Characteristics of Sleep-Wake States and Potential
Neuronal
Targets for Neuropeptide S
Peng Zhao, Yufeng Shao, Min Zhang, Kun Fan, Rui Wang, Yiping
Hou
Antibacterial Activity of Surfactant-Like Linear Amphipathic
Cationic Peptides
Jing Hu, Cui X. Chen, Sheng Z. Zhang, Hai Xu, Jian R. Lu
Comparison of the Pharmacological Functions of the NPFF
and NPFF2 Receptors Ligands
Quan Fang, Ning Li, Rui Wang
Preparation of Monomeric B27 Lys Destripeptide Insulin by
Intein Mediated Expression in E. Coli
Lujuan Li, Helong Hao, Yuanhao Qiao, Ting Chen
Endomorphins Prevent Cardiac Oxidative Damage Induced
by Cadmium Chloride in Rats
Pin Gong, Fuxin Chen, Rui Wang
Study on Anticancer Mechanism of Cyclic Tetrapeptide HDACIs
Shimiao Wang, Xiaohui Li, Zhilong Xiu, Norikazu Nishino
Biological Roles of Hemokinin-1: A Novel Member of
the Tachykinin Family
Ziqing Kong, Wenle Yang, Caiyun Fu, Youli Zhao, Yan Tao, Rui
Wang
Author Index
Subject Index
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